Hair Loss
 
 

DHT


The most common type of hair loss is male or female pattern baldness, also called Androgenetic alopecia (AGA). AGA can be caused by a genetic or hereditary predisposition, aging, or an overproduction of the androgenic hormone, dihydrotestosterone (DHT). This condition is more common in men but may also occur in women during menopause, due to low estrogen levels.

DHT is a highly active form of testosterone known to stimulate prostate growth and scalp hair loss. DHT is also responsible for male behavioral characteristics, including aggression and sex drive. An enzyme produced in the prostate, adrenal glands and scalp, called 5-alpha-reductase, metabolizes the male hormone testosterone into DHT.

Research suggests that DHT may cause an immune reaction against hair follicles in genetically affected areas, where the body's immune system mistakenly identifies hair follicles as foreign tissue and attacks them. Findings show that immune system cells and hair follicle antibodies cluster around the hair follicles of balding men and women.

Other research reports that DHT can cause hair follicles to shrink and enter a permanent dormant state. A 2004 study found that DHT stimulates the production of transforming growth factor-beta2 (TGF-beta2) in hair follicle cells. TGF-beta2 prevents epithelial cell production and eventually causes cell death.

"These lines of evidence strongly suggest the presence of a "catagen cascade" in male pattern baldness, involving: (1) the conversion of testosterone to DHT by type II 5-alpha-reductase; (2) the synthesis of TGF-beta2 in dermal papilla cells; and (3) the activation of the intrinsic caspase network," the study authors conclude. "These sequential events contribute to the shortening of the human hair cycle."

The natural nutrients found in Advecia® and Procerin act as inhibitors that block DHT in the hair follicles and combat the effects of TGF-beta2. Using DHT inhibitors can have a significant role in treating hair loss.

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REFERENCES:
  1. Life Extension eds., Disease Prevention and Treatment, 4th ed. (Hollywood, Florida: Life Extension Media, 2003), Balding, online:
    http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=112617

  2. Stoppard M. Family Health Guide, New York: DK Publishing, 2002: 459-460.

  3. Burke KE. Hair loss. What causes it and what can be done about it. Postgrad Med. 1989 May 1;85(6):52-73, 77.

  4. Rushton DH. Nutritional factors and hair loss. Clin Exp Dermatol. 2002 Jul;27(5):396-404.

  5. Soma T et al. Involvement of transforming growth factor-beta2 in catagen induction during the human hair cycle. J Invest Dermatol 2002 Jun;118(6):993-7.

  6. Hibino T, Nishiyama T. Role of TGF-beta2 in the human hair cycle. J Dermatol Sci. 2004 Jun;35(1):9-18.

  7. Tsuji Y et al. A potential suppressor of TGF-beta delays catagen progression in hair follicles. J Investig Dermatol Symp Proc 2003 Jun;8(1):65-8


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